![]() ![]() Through genetic manipulation, we will disrupt the clock where it still exists in cancer cells, and restore it where it has been disrupted (as in MYC-driven cells), to study the role of the clock in tumor cell growth and physiology. Phylogenetic trees in insects are frequently dated by applying a standard mitochondrial DNA (mtDNA) clock estimated at 2.3 My 1, but despite its wide use reliable calibration points have been lacking. The advent of molecular data started a new era by providing an independent approach to address the history of life on Earth and thus creating a closer connection among geology, paleontology, and biology ().The constancy of molecular evolutionary rate over time, i.e., the molecular clock hypothesis, was suggested early on (). This technique is called the molecular clock, and. ![]() ![]() Our research has shown that the common oncogene MYC disrupts the molecular clock (Altman and Hsieh et al, Cell Metabolism, 2015 Altman et al, Nature Communications, 2017).īut what does that mean for tumor cell growth and survival? We will develop models to study the role of the molecular clock in cells driven by MYC, which is known to disrupt the clock, or other oncogenes such as mutant K-RAS, which does not fully disrupt the clock. Scientists make a few measurements and plug the numbers into an equation to get an estimate of a species age. The circadian clock is known to act as a key regulator in processes of health and disease in different organs. The longer two species have been evolving separately, the more amino acid differences accumulate. in what constitutes a strict molecular clock. These include the adaption of the 24 h sleep-wake rhythm to changes of day and night. Instead of using a conventional molecular model to esti- mate the number of. Recent studies by our lab and other have suggested the same phenomenon in cancer cell lines and in mouse models of cancer. Molecular clocks help organisms to adapt important physiological functions to periodically changing conditions in the environment. How does the molecular clock interact with cancer? Does an active clock promote or suppress cancer formation? Many years of studies have shown that shift workers have a higher incidence of cancer, suggesting that a healthy circadian clock may be tumor-suppressive. ![]()
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